UpNeeq Review: The Newest Treatment For Droopy Eyelids

Upneeq Review

Have you noticed your eyelids are drooping more than they used to?

Do you feel that you have to move your head to see things in your peripheral vision because your eyelids are in the way?

Does the sound of eyelid surgery give you anxiety and sound intimidating?

In this article, I am going to review Upneeq, an exciting new eyedrop that can be safely used to combat these common eyelid complaints and improve the cosmetic appearance of your eyes.

What is acquired blepharoptosis?

Acquired blepharoptosis is the medical name for droopy or low lying eyelids. Acquired ptosis is typically age-related but can affect people of all ages. This condition affects millions of people but studies show only about 15% of people seek out and obtain treatment.

Until now, surgical intervention was the main treatment option. Low lying eyelids can be cosmetically concerning for some people but also impede on activities of daily living ranging from driving to hitting the golf ball to working on a computer.

Related: Eyelid Surgery: What Are the Benefits of a Blepharoplasty?

What is Upneeq?

Upneeq, a new and innovative once daily eyedrop, offers a safe, easy, and quick solution to low-lying lids and is the only FDA approved prescription eyedrop on the market to offer eyelid lift.

Upneeq contains 0.1% oxymetazoline hydrochloride solution that acts as an alpha adrenergic agonist. This component also constricts the blood vessels in the eye, causing the eye to look more white, giving a more youthful appearance.

The dosing of this drop is one drop once a day in each eye and the lift lasts about 8 hours on average (effects can vary). Upneeq can also be used in only one eye, which is helpful for people with unilateral or asymmetrical lids.

Most people see results with this drop in as little as 2 hours, but some people saw immediate results in 10 minutes or less.

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How do I use Upneeq?

Upneeq is a prescription eye drop that anyone can use when prescribed.

Contact lens wearers need to be advised to take the contacts out when instilling Upneeq and then wait 15 minutes prior to putting contact lenses back in. Additionally, wait 10-15 minutes before instilling any other eyedrop to avoid drug washout.

Since the drug does contain an alpha adrenergic agonist component, patients should be advised to discontinue Upneeq if they notice any systemic side effects. This is especially true for patients with high blood pressure or those taking anti-depressant medications.

RELATED: Eyelid Ptosis (Droopy Eyelid): Causes, Symptoms, and Treatments

How do I get Upneeq?

In order to get a prescription for Upneeq, a full comprehensive eye exam with an optometrist or ophthalmologist is necessary.

Ptosis can be related to other more serious conditions, such as certain neurologic conditions, Horner’s syndrome, myasthenia gravis, orbital infection, and orbital masses, and others, thus a comprehensive eye exam is important.

Most optometrists are given samples of Upneeq to hand out to patients to trial for themselves to ensure they are happy with the results. From there, you can order a 30 or 90 day supply of Upneeq through the optometrist’s office.

RELATED: Best Eyelid Products For Blepharitis Treatment

Pros and Cons of using Upneeq


  • Upneeq is bought straight from RVL pharmacy so no worrying about insurance
  • Shipped directly to your home
  • Can mimic Lumify / Visine for redness reduction
  • Works quickly
  • Just one drop does the trick
  • Single use droppers, so you are able to use the drop when you want to and don’t have to worry about opening a bottle of drops and having them expire before you can finish the bottle


  • 1-5% of patients experience mild symptoms such as dry eye (punctate keratitis), red eyes (conjunctival hyperemia), transient blurred vision, eye irritation, and headache
  • Costs more than most other drops since insurance cannot be applied

How much does Upneeq cost?

Upneeq can be purchased in either 30 single use droppers costing $105 or 90 single use droppers costing $255. Each dropper contains about 4 drops.

Upneeq Before and After Photos

Patient 1 
Patient 2
Patient 3

These pictures show before and after images of people using Upneeq. The after image is shown 1 hour after instilling 1 drop of Upneeq in both eyes. Notice both the eyelid lift as well as the whitening of the eyes.

RELATED: Lumify Eye Drops Review – Is Lumify Better Than Other Red Eye Drops?

Final thoughts

Upneeq is the first drop of its kind and offers an exciting new approach to the world of aesthetic eyecare. Every eye responds differently to this drop, but I have been impressed with the results.

Personally, I enjoy educating patients on this new non-surgical and practical approach to help with their eyelid issues as well as offering the latest innovation in eye care.

At the end of the day, who doesn’t want to look more youthful and awake? I encourage everyone to trial this drop and see the results for themselves!

Author bio: Dr. Hannah Cornelia is an optometrist practicing in sunny Charleston, SC. Originally from Georgia, She attended the University of Georgia then earned her doctorate from the UAB School of Optometry in 2019. She practices in a full scope medically oriented private practice. She thoroughly enjoys the connection between overall health and ocular health and loves incorporating health and wellness concepts into her practice. Outside of work, she can be found enjoying the Charleston beaches and food scene as well as traveling.